The museum is housed within the former Augustinian convent of Santa Croce. Access is through the large cloister, frescoed in the early 17th century with stories from the life of Saint Nicholas of Tolentino by the painter Guglielmo Caccia, known as Il Moncalvo. The museum's collection is the result of a variety of donations by Casale citizens, initially brought together in a civic collection in the mid 19th century. There are many works by Piedmontese and Lombard artists such as Martino Spanzotti, Niccolò Musso, Francesco Cairo, Pietro Francesco Guala, Angelo Morbelli and others, as well as wooden and ceramic sculptures. The archaeological section is home to the display "Longobards in Monferrato: Archaeology of the Iudiciaria Torrensis".
The "Leonardo Bistolfi Gipsoteca" is located on the ground floor and contains over 170 works by the Casalese symbolist sculptor, including terracottas, drawings, models, plaster casts, marbles and bronzes.
A splendid 15th-century portal from the former church of Santa Maria di Piazza can be found in the small cloister.
During the "Castelli Aperti" initiative (second weekwend of every months) free guided tours are available of the Torre Civica, the Theater, churches and palaces, starting at 3 pm every second Sunday of the month.
The civic museum is regularly open to the public throughout the year, with a entrance fee.
Basso Monferrato castles, Sanctuary and Sacro Monte di Crea.
"Casale Città Aperta" and antiques market (second weekend of the month), "Fiera di San Giuseppe" (March), "Riso e Rose" (May), "Festa del Vino e del Monferrato" wine festival (September).